Labels:text | screenshot | black | black and white | font | document OCR: h of IGFZ is Hypoglycaemia caused by overproductic than one the result of a sequence of events, rather e tumour single event. Initially, IGF2 released by t lasma and is bound by IGF-binding proteins in the sulin becomes unavailable for binding to the weak receptors on cells, for which it has only affinity. Eventually, however, the IGF2 suppress wth production and secretion of pituitary gr hormone, possibly by a negative feedbac batic mechanism, and this in turn reduces he is, it is production of both IGFI and IGF-BP3. TI plasma postulated, leads to a further reduction i the IGF2 binding capacity and, consequently presence in the plasma of more free or normal. nonprotein-bound IGF2 and/or IGFI the This can and does exert an insulin-like hypoglycaemic action.
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